Obesogen : Toxin and obesity



What is Obesogen?


Obesogens are chemicals that disrupt the body's normal homeostatic controls in such a way as to promote adipogenesis and lipid accumulation.


These agents can act by any of several mechanisms such as

  • disrupting RNA transcriptional control

  • interfering with normal activity of steroid hormones

  • disrupting the normal metabolic balance


Source of obesogen


Click to see Obesogen list


  • Nicotine

  • Dioxin from pollution

  • Dichlorodiphenyl-trichloroethane (DDT) from biocide

  • Bisphenol A (BPA) from a plastic bottle

  • phthalates : personal care, household product see the list

  • PFOA : industrial surfactant


They are chemicals to which individuals are exposed on an almost continuous basis, in the foods and beverages they consume and the products they use.



Reference

  1. Mallory D. Griffin, Sean R. Pereira, Megan K. DeBari and Rosalyn D. Abbott"Mechanisms of action, chemical characteristics, and model systems of obesogens" BMC Biomedical Engineering (2020)




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